The Nina Bliese Gallery is located on the main floor lobby level of the striking 53-story 225 SOUTH SIXTH tower designed by Pei Cobb Freed & Partners. The building is located on Sixth Street between Second and Third Avenue in the heart of financial and judicial district in downtown Minneapolis.

Parking is available in the building (ramp entrance on South 7th Street and 3rd Avenue South) or in numerous nearby ramps such as the Northstar/Crown Plaza across the street.